Dr. Marc Grynpas	Dr. Marc Grynpas Professor of Laboratory Medicine and Pathobiology, University of Toronto Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Mount Sinai Hospital Samuel Lunenfeld Research Institute 600 University Avenue, Room 840 Toronto, Ontario, Canada M5G 1X5 Phone: 416-586-4464 Fax: 416-586-1554 grynpas@mshri.on.ca www.mshri.on.ca/grynpas/default.asp
Current academic / hospital appointments
Senior Scientist, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Professor, Department of Laboratory Medicine & Pathobiology, University of Toronto Director, Bone And Mineral Group, Faculty of Medicine, University of Toronto Professor, Material Sciences and Engineering, , University of Toronto Professor, Institute for Biomaterials & Biomedical Engineering, University of Toronto Director, Kidney Stone Analysis Laboratory, Department of Pathology and Laboratory Medicine, Mount Sinai Hospital
Education
1970 - License, Brussels University, Brussels, Belgium (Physics) 1970 - Aggregation, Brussels University, Brussels, Belgium (Teaching) 1975 – Ph.D. Birkbeck College, University of London, England (Crystallography / Biophysics)
Courses
Graduate / Postgraduate: The biology of connective tissues “Structure and Chemistry of the Organic and Mineral Phase of Bone: Mechanisms of Mineralization” (2H). Clinical Biochemistry 1603 “Bone Chemistry and Mineralization” (1H). The Pathology of Connective Tissue “The Pathophysiology of Mineralized Tissues (4H) and Connective Tissue Biomaterials Interaction” (2H). Biomaterials Science (JTC 1331F) “Structure and Function of Bone” (3H). Physiology: Calcium metabolism (PSL 1048) “Physico-Chemical Mechanisms of Mineralization” (2H). Pathology (1007Y) “Bone and Joint Pathology” (6H). Mechanisms of Disease (PAT 1007) (2H) Biomaterials and Biocompatibility (MMS 4525) (4H) Bone and Skeletal disorders (LMP404H) (6H)
Research interests
Structure and chemistry of bone mineral and matrix Changes in bone mineral with age and diseases Chemistry and organization of cartilaginous tissues Effect of trace elements on bone Space induced demineralization Animal models for osteopenia Effect of diagenesis on bone Vascular calcification Biomaterials Skeletal biology of non-human primates Effect of drugs on the structure, chemistry and mechanical properties of bone Biodegradable implants Orthopaedic rehabilitation Kidney stones
Recent publications
Seguin CA, Grynpas MD, Pilliar RM, Waldman SD, Kandel RA. Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrate. Spine, 2004 June 15;29(12):1299-306;discussion 1306-7 Vieira APGF, Hancock R, Limeback H, Maia R, Grynpas MD. Is Fluoride Concentration in Dentin and Enamel a good Indicator of Dental Fluorosis? J.Dental Res. (2004) 83(1):76-80. Goss PE, Qi S, Josse R, Pritzker KPH, Mendes M, Hu H, Grynpas MD. The Steroidal Aromatase Inhibitor Exemestane Prevents Bone Loss in Ovariectomized Rats. Bone (2004) Mar;34(3):384-92. Djokoto C, Tomlinson G, Waldman S, Grynpas MD, Cheung AM. Relationship between MRTA, DEXA and QUS. J. Clin.Densitometry. (2003) in press Evan AP, Lingeman JE, Coe FL, Shao Y, Parks JH, Bledsoe SB, Worcester EM, Sommer AJ, Paterson RF, Kuo RL and Grynpas MD. Brushite Nephrolithiasis: Delineation of a New Kidney Disease. (2003) in press
Awards and Honours
National Research Service Award, National Institute of Arthritis, Metabolism and Digestive Diseases, NIH National Aeronautics and Space Administration, Cosmos Achievement Award Sherring award at the International Conference on Osteoporosis. Teaching Award for Graduate Education, Department of Laboratory Medicine and Pathobiology, University of Toronto University – Industry Research Chair (MRC / Ciba-Geigy) Scientific Officer, Arthritis Society Grant Panel Member, Grant Panel (Dental Sciences), Canadian Institute of Health Head Scientific Advisory Committee of the Advance Bioimaging Centre Member Scientific Advisory Board, International Conference on the Chemistry and Biology of Mineralized Tissues
Editorships
Bone
Students
Sidney Omelon (Ph.D. Candidate), MA.Sc. (McGill University), Ph.D. Thesis title: “Mechanisms of formation and dissolution of calcium polyphosphates” Anya Vieira (Ph.D. Candidate), DDS,M.Sc. (London), Ph.D. Thesis title: “Enamel and dentine in dental fluorosis” Lisa Wise (Ph.D. Candidate), B.Sc. (Guelph University), Ph.D title: “Bone quality in mice models of human diseases” Chrystia Wynnyckyj (Ph.D. Candidate), MA.Sc. (University of Toronto), Ph.D. Thesis title: “The interface between calcium polyphosphates implants and calcified tissue” Diana Facchini (MA.Sc. Candidate), B.Sc. (University of Toronto), M.Sc Thesis title: "Effect of vandium treatment on bone loss and bone quality in rat models of osteoporosis and diabetes" Briana Illingworth (MA.Sc. Candidate), B.Sc. (University of Toronto), M.Sc Thesis title: “Studies of mechanisms of calcium polyphosphates formation” Elizabeth Rowe (MA.Sc. Candidate), B.Sc. (University of Toronto), M.Sc.Thesis title: “The effects of growth hormone peptides on bone quality in a rat model of osteoporosis” Andrew Chiu (MA.Sc. Candidate), B.Sc. (University of Toronto), M.Sc Thesis title: "Effect of vandium treatment on bone loss and bone quality in rat models of osteoporosis and diabetes – Phase II" * Presently accepting students for supervision.
Current research grants
Canadian Institutes of Health Research (CIHR) - “Effect of Vanadium Treatment on Bone Loss and Bone Quality in Rat Models of Osteoporosis and Diabetes” National Science Engineering and Research Council of Canada – “Mechanisms of Degradation of Calcium – Polyphosphates” National Science Engineering Research Council - “Tissue-Engineered for Cartilage Repair” (Collaborative) Canadian Institutes of Health Research (CIHR) - “The Role of Stem Cell Antigen-1 (Sca-1) in Bone Development and Homeostasis” (Collaborative) Canadian Institutes of Health Research (CIHR) – “Importance of harikiri in regulation of oocyte and embryo survival” (Collaborative) Canadian Institutes of Health Research (CIHR) – “The clinical utility of the mechanicial response Tissue analyser device for determining bone fragility” (Collaborative) Canadian Institutes of Health Research (CIHR) - New Emerging Team: Aging (Collaborative) Canadian Institutes of Health Research (CIHR) - Maintenance and Support for the Advance Bioimaging Centre (Collaborative)